Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi.

Author: 

Wiederhold NP, Patterson TF, Srinivasan A, Chaturvedi AK, Fothergill AW, Wormley FL, Ramasubramanian AK, Lopez-Ribot JL.
Virulence. 2017 Feb 17;8(2):138-142.

Abstract: 

Repositioning old drugs can significantly decrease the time and effort that it takes to develop novel antifungal therapeutics, which represents a pressing and unmet clinical need due to the devastating nature of fungal infections. We have previously described the activity of auranofin, a gold thiol compound used to treat rheumatoid arthritis, against Candida albicans biofilms. Here we evaluate its antifungal spectrum of action and describe its activity against a variety of medically important fungi.

KEYWORDS:

antifungal susceptibility; auranofin; repurposing; spectrum of action