Paediatric Fungal infections

This section summarises published information regarding the concepts in managing invasive fungal infections in children, with specific reference to Aspergillus.

Broadly there are two sections comprising diagnosis and treatment regimes. The data here are sourced and summarised from a series of publications in Clinical Microbiology Infect. 16(9), 1319-53, 2010 by Groll et alWalsh et alDornbusch et al& all these references are more comprehensive than the data compiled here and we recommend referral to the original publications for further detail. 
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Children and in particular neonates and young infants, are a unique patient population, particularly with respect to fungal infections. 
Invasive fungal infections are dificult to diagnose - but response to treatment and outcome is dependent on a prompt initial diagnosis and the initiation of treatment.

Epidemiology and Clinical Trials

The epidemiology, presentation and pre-disposing conditions show significant differences in paediatric versus adult patients. 
The use of antifungal agents in this patient group requires an understanding of pharmacodynamics and safety issues - which accumulating evidence suggests can not always be empirically derived from data collected on usage in adult groups.

Many antifungal clinical trials have previously excluded paediatric groups so there is a lack of trials of large cohorts- but there is data in the literature for smaller cohorts of paediatric patients- for various antifungal treatments.
New antifungals are continually going into trials - however the need for evaluation in paediatric patients is great.

This website specialises in Aspergillus infections - but the lack of paediatric data has meant that we have included data for other types of fungal infections - where it may be useful. 

Computed content type (Paediatrics): 


Paediatric articles

Displaying 1 - 10 of 117
Author year
Chronic Aspergillus fumigatus colonization of the pediatric cystic fibrosis airway is common and may be associated with a more rapid decline in lung function. Saunders RV, Modha DE, Claydon A, Gaillard EA. 2017
Evaluación de interacción medicamentosa de voriconazol-ciclosporina en pacientes pediátricos que reciben trasplante de precursores hematopoyéticos (2013-2014) [Drug interaction of voriconazole-cyclosporine in children undergoing hematopoietic stem cell t Romina Valenzuela, Juan P. Torres, Carolina Salas, Iván Gajardo, Julia Palma, Paula Catalán, M. Elena Santolaya y Jorge Morales 2017
Voriconazole Dosing in Children Younger Than 3 Years Undergoing Cancer Chemotherapy or Hematopoietic Stem Cell Transplantation. Yan SQ, Seyboth B, Kobos R, Eaton A, Seo SK, Cohen N. 2017
Risk and Protective Factors for Childhood Asthma: What Is the Evidence? Castro-Rodriguez JA, Forno E, Rodriguez-Martinez CE, Celedón JC. 2017
Infección fúngica invasora en niños: diferencias y homologías con el adulto [Invasive fungal infections in children: similarities and differences with adults].[Article in Spanish] Ramos JT, Francisco L, Daoud Z. 2016
Invasive fungal sinusitis in the pediatric population: Systematic review with quantitative synthesis of the literature. Smith A, Thimmappa V, Shepherd B, Ray M, Sheyn A, Thompson J. 2016
High infection-related mortality in pediatric acute myeloid leukemia without preventive antibiotics and antifungals. Retrospective cohort study of a single center from a middle-income country. Zengin E, Sarper N, Gelen SA, Demirsoy U, Karadoğan M, Çakı Kılıç S, Öncel S, Arısoy ES, Dündar D. 2017
Utility of the Aspergillus galactomannan antigen testing for neutropenic paediatric patients. Sav H, Atalay MA, Koc AN, Unal E, Demir G, Zararsiz G. 2017
Antifungal Immunological Defenses in Newborns. Michalski C, Kan B, Lavoie PM. 2017
Efficacy, safety and feasibility of antifungal prophylaxis with posaconazole tablet in paediatric patients after haematopoietic stem cell transplantation. Döring M, Cabanillas Stanchi KM, Queudeville M, Feucht J, Blaeschke F, Schlegel P, Feuchtinger T, Lang P, Müller I, Handgretinger R, Heinz WJ. 2017