Paediatric Fungal infections

This section summarises published information regarding the concepts in managing invasive fungal infections in children, with specific reference to Aspergillus.

Broadly there are two sections comprising diagnosis and treatment regimes. The data here are sourced and summarised from a series of publications in Clinical Microbiology Infect. 16(9), 1319-53, 2010 by Groll et alWalsh et alDornbusch et al& all these references are more comprehensive than the data compiled here and we recommend referral to the original publications for further detail. 
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Children and in particular neonates and young infants, are a unique patient population, particularly with respect to fungal infections. 
Invasive fungal infections are dificult to diagnose - but response to treatment and outcome is dependent on a prompt initial diagnosis and the initiation of treatment.


Epidemiology and Clinical Trials

The epidemiology, presentation and pre-disposing conditions show significant differences in paediatric versus adult patients. 
The use of antifungal agents in this patient group requires an understanding of pharmacodynamics and safety issues - which accumulating evidence suggests can not always be empirically derived from data collected on usage in adult groups.


Many antifungal clinical trials have previously excluded paediatric groups so there is a lack of trials of large cohorts- but there is data in the literature for smaller cohorts of paediatric patients- for various antifungal treatments.
New antifungals are continually going into trials - however the need for evaluation in paediatric patients is great.


This website specialises in Aspergillus infections - but the lack of paediatric data has meant that we have included data for other types of fungal infections - where it may be useful. 

Computed content type (Paediatrics): 

Paediatrics

Paediatric articles

Displaying 1 - 10 of 124
Author year
Performance of 1,3-β-D-glucan for diagnosing invasive fungal diseases in children Calitri C, Caviglia I, Cangemi G, Furfaro E, Bandettini R, Fioredda F, Amoroso L, Faraci M, Risso FM, Mattioli G, Moscatelli A, Haupt R, Castagnola E. 2017
Performance of 1,3-β-D-glucan for diagnosing invasive fungal diseases in children Calitri C, Caviglia I, Cangemi G, Furfaro E, Bandettini R, Fioredda F, Amoroso L, Faraci M, Risso FM, Mattioli G, Moscatelli A, Haupt R, Castagnola E. 2017
Voriconazole Antifungal Prophylaxis in Children With Malignancies: A Nationwide Study Pana ZD, Kourti M, Vikelouda K, Vlahou A, Katzilakis N, Papageorgiou M, Doganis D, Petrikkos L, Paisiou A, Koliouskas D, Kattamis A, Stiakaki E, Chatzistilianou M, Vasilatou-Kosmidis H, Polychronopoulou S, Grafakos S, Roilides E. 2017
Simultaneous primary invasive cutaneous aspergillosis in two preterm twins: case report and review of the literature Gallais F, Denis J, Koobar O, Dillenseger L, Astruc D, Herbrecht R, Candolfi E, Letscher-Bru V, Sabou M. 2017
Gastrointestinal Basidiobolomycosis: An Emerging, and A Confusing, Disease in Children (A Multicenter Experience) Shreef K, Saleem M, Saeedd MA, Eissa M 2017
Anidulafungin in children: Experience in a tertiary care children's hospital in Argentina. Rosanova MT, Sarkis C, Escarra F, Epelbaum C, Sberna N, Carnovale S, Figueroa C, Bologna R, Lede R. 2017
Pathogen screening and prognostic factors in children with severe ARDS of pulmonary origin. Phung TTB, Suzuki T, Phan PH, Kawachi S, Furuya H, Do HT, Kageyama T, Ta TA, Dao NH, Nunoi H, Tran DM, Le HT, Nakajima N. 2017
Progress in the Diagnosis of Invasive Fungal Disease in Children. Warris A, Lehrnbecher T. 2017
Pediatric invasive fungal rhinosinusitis: An investigation of 17 patients. Vinh D, Yim M, Dutta A, Jones JK, Zhang W, Sitton M. 2017
Chronic Aspergillus fumigatus colonization of the pediatric cystic fibrosis airway is common and may be associated with a more rapid decline in lung function. Saunders RV, Modha DE, Claydon A, Gaillard EA. 2017

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